Tributyrin Inhibits Ethanol-Induced Epigenetic Repression of CPT-1A and Attenuates Hepatic Steatosis and InjurySummary

Tributyrin Inhibits Ethanol-Induced Epigenetic Repression of CPT-1A and Attenuates Hepatic Steatosis and InjurySummary

Ethanol-mediated down-regulation of carnitine palmitoyltransferase-1 (CPT-1A) gene expression plays a major role in the development of hepatic steatosis; however, the underlying mechanisms are not completely elucidated. Tributyrin, a butyrate prodrug that can inhibit histone deacetylase (HDAC) activ...

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Bibliographic Details
Main Authors: Hridgandh Donde, Smita Ghare, Swati Joshi-Barve, JingWen Zhang, Manicka V. Vadhanam, Leila Gobejishvili, Pawel Lorkiewicz, Sanjay Srivastava, Craig J. McClain, Shirish Barve
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Epigenetic Promoter Modification
Gene Regulation
Alcoholic Liver Disease
Hepatocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X19301419

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http://www.sciencedirect.com/science/article/pii/S2352345X19301419

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