Enzyme-Constrained Models and Omics Analysis of Streptomyces coelicolor Reveal Metabolic Changes that Enhance Heterologous Production

Enzyme-Constrained Models and Omics Analysis of Streptomyces coelicolor Reveal Metabolic Changes that Enhance Heterologous Production

Summary: Many biosynthetic gene clusters (BGCs) require heterologous expression to realize their genetic potential, including silent and metagenomic BGCs. Although the engineered Streptomyces coelicolor M1152 is a widely used host for heterologous expression of BGCs, a systemic understanding of how...

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Bibliographic Details
Main Authors: Snorre Sulheim, Tjaša Kumelj, Dino van Dissel, Ali Salehzadeh-Yazdi, Chao Du, Gilles P. van Wezel, Kay Nieselt, Eivind Almaas, Alexander Wentzel, Eduard J. Kerkhoven
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:iScience
Subjects:
Systems Biology
Omics
Metabolic Engineering
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220307173

Internet

http://www.sciencedirect.com/science/article/pii/S2589004220307173

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