Blood transcriptomic discrimination of bacterial and viral infections in the emergency department: a multi-cohort observational validation study

Blood transcriptomic discrimination of bacterial and viral infections in the emergency department: a multi-cohort observational validation study

Abstract Background There is an urgent need to develop biomarkers that stratify risk of bacterial infection in order to support antimicrobial stewardship in emergency hospital admissions. Methods We used computational machine learning to derive a rule-out blood transcriptomic signature of bacterial...

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Bibliographic Details
Main Authors: Dayle Sampson, Thomas D. Yager, Brian Fox, Laura Shallcross, Leo McHugh, Therese Seldon, Antony Rapisarda, Richard B. Brandon, Krupa Navalkar, Nandi Simpson, Sian Stafford, Eliza Gil, Cristina Venturini, Evi Tsaliki, Jennifer Roe, Benjamin Chain, Mahdad Noursadeghi
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Medicine
Subjects:
Blood transcriptional profiling
Bacterial infection, viral infection
Emergency department
Online Access:http://link.springer.com/article/10.1186/s12916-020-01653-3

Internet

http://link.springer.com/article/10.1186/s12916-020-01653-3

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