Pharmacological reversal of histone methylation presensitizes pancreatic cancer cells to nucleoside drugs: in vitro optimization and novel nanoparticle delivery studies.

Pharmacological reversal of histone methylation presensitizes pancreatic cancer cells to nucleoside drugs: in vitro optimization and novel nanoparticle delivery studies.

We evaluated the potential of an investigational histone methylation reversal agent, 3-deazaneplanocin A (DZNep), in improving the chemosensitivity of pancreatic cancer to nucleoside analogs (i.e., gemcitabine). DZNep brought delayed but selective cytotoxicity to pancreatic cancer cells without affe...

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Bibliographic Details
Main Authors: Sau Wai Hung, Hardik Mody, Sean Marrache, Yangzom D Bhutia, Franklin Davis, Jong Hyun Cho, Jason Zastre, Shanta Dhar, Chung K Chu, Rajgopal Govindarajan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3735519?pdf=render

Internet

http://europepmc.org/articles/PMC3735519?pdf=render

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