Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology

Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology

Alpha-Synuclein (α-syn) is by far the most highly vetted pathogenic and therapeutic target in Parkinson's disease. Aggregated α-syn is present in sporadic Parkinson's disease, both in the central nervous system (CNS) and peripheral nervous system (PNS). The enteric division of the PNS is o...

Full description

Bibliographic Details
Main Authors: Fredric P. Manfredsson, Kelvin C. Luk, Matthew J. Benskey, Aysegul Gezer, Joanna Garcia, Nathan C. Kuhn, Ivette M. Sandoval, Joseph R. Patterson, Alana O'Mara, Reid Yonkers, Jeffrey H. Kordower
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Neurobiology of Disease
Subjects:
Alpha-synuclein
Enteric nervous system
Parkinson's disease
Enteric dysfunction
Prion spread
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118300081

Internet

http://www.sciencedirect.com/science/article/pii/S0969996118300081

Similar Items