Oral Antibiotic Treatment of Mice Exacerbates the Disease Severity of Multiple Flavivirus Infections

Summary: Although the outcome of flavivirus infection can vary from asymptomatic to lethal, environmental factors modulating disease severity are poorly defined. Here, we observed increased susceptibility of mice to severe West Nile (WNV), Dengue, and Zika virus infections after treatment with oral...

Full description

Bibliographic Details
Main Authors: Larissa B. Thackray, Scott A. Handley, Matthew J. Gorman, Subhajit Poddar, Prachi Bagadia, Carlos G. Briseño, Derek J. Theisen, Qing Tan, Barry L. Hykes, Jr., Hueylie Lin, Tiffany M. Lucas, Chandni Desai, Jeffrey I. Gordon, Kenneth M. Murphy, Herbert W. Virgin, Michael S. Diamond
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718303152