Scn1b deletion in adult mice results in seizures and SUDEP

Scn1b deletion in adult mice results in seizures and SUDEP

Abstract Pathogenic loss‐of‐function variants in SCN1B are linked to Dravet syndrome (DS). Previous work suggested that neuronal pathfinding defects underlie epileptogenesis and SUDEP in the Scn1b null mouse model of DS. We tested this hypothesis by inducing Scn1b deletion in adult mice that had dev...

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Bibliographic Details
Main Authors: Heather A. O'Malley, Jacob M. Hull, Brittany C. Clawson, Chunling Chen, Gic Owens‐Fiestan, Margaret B. Jameson, Sara J. Aton, Jack M. Parent, Lori L. Isom
Format: Article
Language:English
Published: Wiley 2019-06-01
Series:Annals of Clinical and Translational Neurology
Online Access:https://doi.org/10.1002/acn3.785

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https://doi.org/10.1002/acn3.785

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