Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma
SUMMARY Neuroblastoma is a childhood extracranial solid tumour that is associated with a number of genetic changes. Included in these genetic alterations are mutations in the kinase domain of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK), which have been found in both somatic a...
Main Authors: | , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2013-03-01
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Series: | Disease Models & Mechanisms |
Online Access: | http://dmm.biologists.org/content/6/2/373 |