Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection

Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection

Recent insights into the mechanisms by which Mycobacterium tuberculosis, the etiologic agent of human tuberculosis, is recognized by cytosolic nucleotide sensors have opened new avenues for rational vaccine design. The only licensed anti-tuberculosis vaccine, Mycobacterium bovis BCG, provides limite...

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Bibliographic Details
Main Authors: Matthias I. Gröschel, Fadel Sayes, Sung Jae Shin, Wafa Frigui, Alexandre Pawlik, Mickael Orgeur, Robin Canetti, Nadine Honoré, Roxane Simeone, Tjip S. van der Werf, Wilbert Bitter, Sang-Nae Cho, Laleh Majlessi, Roland Brosch
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
tuberculosis
Mycobacterium tuberculosis
recombinant BCG
ESX/type VII secretion
vaccination
Mycobacterium marinum
cytosolic pattern recognition
innate immune signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302553

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http://www.sciencedirect.com/science/article/pii/S2211124717302553

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