Discovery of a Natural Product That Binds to the <i>Mycobacterium tuberculosis</i> Protein Rv1466 Using Native Mass Spectrometry

Discovery of a Natural Product That Binds to the <i>Mycobacterium tuberculosis</i> Protein Rv1466 Using Native Mass Spectrometry

Elucidation of the mechanism of action of compounds with cellular bioactivity is important for progressing compounds into future drug development. In recent years, phenotype-based drug discovery has become the dominant approach to drug discovery over target-based drug discovery, which relies on the...

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Bibliographic Details
Main Authors: Ali R. Elnaas, Darren Grice, Jianying Han, Yunjiang Feng, Angela Di Capua, Tin Mak, Joseph A. Laureanti, Garry W. Buchko, Peter J. Myler, Gregory Cook, Ronald J. Quinn, Miaomiao Liu
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Molecules
Subjects:
altholactone
tuberculosis
Rv1466
drug target
native mass spectrometry
Online Access:https://www.mdpi.com/1420-3049/25/10/2384

Internet

https://www.mdpi.com/1420-3049/25/10/2384

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