Pharmacokinetics in Zebrafish Embryos (ZFE) Following Immersion and Intrayolk Administration: A Fluorescence-Based Analysis

Pharmacokinetics in Zebrafish Embryos (ZFE) Following Immersion and Intrayolk Administration: A Fluorescence-Based Analysis

Zebrafish embryos (ZFE) have increasingly gained in popularity as a model to perform safety screenings of compounds. Although immersion of ZFE is the main route of exposure used, evidence shows that not all small molecules are equally absorbed, possibly resulting in false-negative readouts and incor...

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Bibliographic Details
Main Authors: Marlly Guarin, Annelii Ny, Noémie De Croze, Jan Maes, Marc Léonard, Pieter Annaert, Peter A. M. de Witte
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceuticals
Subjects:
zebrafish embryo
fish embryo toxicity test (FET)
pharmacokinetics
non-compartmental analysis
fluorescent compounds
exposure routes
Online Access:https://www.mdpi.com/1424-8247/14/6/576

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https://www.mdpi.com/1424-8247/14/6/576

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