Loss of CD96 Expression as a Marker of HIV-Specific CD8+ T-Cell Differentiation and Dysfunction

Loss of CD96 Expression as a Marker of HIV-Specific CD8+ T-Cell Differentiation and Dysfunction

Persistent immune activation and inflammation in people living with HIV (PLWH) are associated with immunosenescence, premature aging and increased risk of non-AIDS comorbidities, with the underlying mechanisms not fully understood. In this study, we show that downregulation of the T-cell immunoglobu...

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Bibliographic Details
Main Authors: Rémi Bunet, Manon Nayrac, Hardik Ramani, Mohamed Sylla, Madeleine Durand, Carl Chartrand-Lefebvre, Jean-Pierre Routy, Alan L. Landay, Jean-Francois Gauchat, Nicolas Chomont, Petronela Ancuta, Daniel E. Kaufmann, Nicole Bernard, Cécile L. Tremblay, Mohamed El-Far
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
HIV
CD96
people living with HIV (PLWH)
T-cell senescence
T-cell dysfunction, IL-32
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.673061/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.673061/full

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