Beyond multidrug resistance: Leveraging rare variants with machine and statistical learning models in Mycobacterium tuberculosis resistance predictionResearch in context

Background: The diagnosis of multidrug resistant and extensively drug resistant tuberculosis is a global health priority. Whole genome sequencing of clinical Mycobacterium tuberculosis isolates promises to circumvent the long wait times and limited scope of conventional phenotypic antimicrobial susc...

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Bibliographic Details
Main Authors: Michael L. Chen, Akshith Doddi, Jimmy Royer, Luca Freschi, Marco Schito, Matthew Ezewudo, Isaac S. Kohane, Andrew Beam, Maha Farhat
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419302506