Predisposition to cancer caused by genetic and functional defects of mammalian Atad5.

Predisposition to cancer caused by genetic and functional defects of mammalian Atad5.

ATAD5, the human ortholog of yeast Elg1, plays a role in PCNA deubiquitination. Since PCNA modification is important to regulate DNA damage bypass, ATAD5 may be important for suppression of genomic instability in mammals in vivo. To test this hypothesis, we generated heterozygous (Atad5(+/m)) mice t...

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Main Authors: Daphne W Bell, Nilabja Sikdar, Kyoo-Young Lee, Jessica C Price, Raghunath Chatterjee, Hee-Dong Park, Jennifer Fox, Masamichi Ishiai, Meghan L Rudd, Lana M Pollock, Sarah K Fogoros, Hassan Mohamed, Christin L Hanigan, NISC Comparative Sequencing Program, Suiyuan Zhang, Pedro Cruz, Gabriel Renaud, Nancy F Hansen, Praveen F Cherukuri, Bhavesh Borate, Kirk J McManus, Jan Stoepel, Payal Sipahimalani, Andrew K Godwin, Dennis C Sgroi, Maria J Merino, Gene Elliot, Abdel Elkahloun, Charles Vinson, Minoru Takata, James C Mullikin, Tyra G Wolfsberg, Philip Hieter, Dae-Sik Lim, Kyungjae Myung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3161924?pdf=render

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http://europepmc.org/articles/PMC3161924?pdf=render

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