GSTT1 and GSTM1 null variants in Mestizo and Amerindian populations from northwestern Mexico and a literature review
Abstract The GSTT1 and GSTM1 genes are key molecules in cellular detoxification. Null variants in these genes are associated with increase susceptibility to developing different types of cancers. The aim of this study was to determine the prevalence of GSTT1 and GSTM1 null genotypes in Mestizo and A...
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2017-11-01
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doaj-f804e48d256442d1b9006110021ceb6f2020-11-25T02:55:10ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-46852017-11-01010.1590/1678-4685-gmb-2016-0142S1415-47572017005027102GSTT1 and GSTM1 null variants in Mestizo and Amerindian populations from northwestern Mexico and a literature reviewLuz Elena Palma-CanoEmilio J. CórdovaLorena OrozcoAngélica Martínez-HernándezMiguel CidIrene Leal-BerumenAngel Licón-TrilloRuth Lechuga-VallesMauricio González-PonceEverardo González-RodríguezVerónica Moreno-BritoAbstract The GSTT1 and GSTM1 genes are key molecules in cellular detoxification. Null variants in these genes are associated with increase susceptibility to developing different types of cancers. The aim of this study was to determine the prevalence of GSTT1 and GSTM1 null genotypes in Mestizo and Amerindian individuals from the Northwestern region of Mexico, and to compare them with those reported worldwide. GSTT1 and GSTM1 null variants were genotyped by multiplex PCR in 211 Mestizos and 211 Amerindian individuals. Studies reporting on frequency of GSTT1 and GSTM1 null variants worldwide were identified by a PubMed search and their geographic distribution were analyzed. We found no significant differences in the frequency of the null genotype for GSTT1 and GSM1 genes between Mestizo and Amerindian individuals. Worldwide frequencies of the GSTT1 and GSTM1 null genotypes ranges from 0.10 to 0.51, and from 0.11 to 0.67, respectively. Interestingly, in most countries the frequency of the GSTT1 null genotype is common or frequent (76%), whereas the frequency of the GSMT1 null genotype is very frequent or extremely frequent (86%). Thus, ethnic-dependent differences in the prevalence of GSTT1 and GSTM1 null variants may influence the effect of environmental carcinogens in cancer risk.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017005027102&lng=en&tlng=enOxidative stressGSTT1GSTM1null variants |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luz Elena Palma-Cano Emilio J. Córdova Lorena Orozco Angélica Martínez-Hernández Miguel Cid Irene Leal-Berumen Angel Licón-Trillo Ruth Lechuga-Valles Mauricio González-Ponce Everardo González-Rodríguez Verónica Moreno-Brito |
spellingShingle |
Luz Elena Palma-Cano Emilio J. Córdova Lorena Orozco Angélica Martínez-Hernández Miguel Cid Irene Leal-Berumen Angel Licón-Trillo Ruth Lechuga-Valles Mauricio González-Ponce Everardo González-Rodríguez Verónica Moreno-Brito GSTT1 and GSTM1 null variants in Mestizo and Amerindian populations from northwestern Mexico and a literature review Genetics and Molecular Biology Oxidative stress GSTT1 GSTM1 null variants |
author_facet |
Luz Elena Palma-Cano Emilio J. Córdova Lorena Orozco Angélica Martínez-Hernández Miguel Cid Irene Leal-Berumen Angel Licón-Trillo Ruth Lechuga-Valles Mauricio González-Ponce Everardo González-Rodríguez Verónica Moreno-Brito |
author_sort |
Luz Elena Palma-Cano |
title |
GSTT1 and GSTM1 null variants in Mestizo and Amerindian populations from northwestern Mexico and a literature review |
title_short |
GSTT1 and GSTM1 null variants in Mestizo and Amerindian populations from northwestern Mexico and a literature review |
title_full |
GSTT1 and GSTM1 null variants in Mestizo and Amerindian populations from northwestern Mexico and a literature review |
title_fullStr |
GSTT1 and GSTM1 null variants in Mestizo and Amerindian populations from northwestern Mexico and a literature review |
title_full_unstemmed |
GSTT1 and GSTM1 null variants in Mestizo and Amerindian populations from northwestern Mexico and a literature review |
title_sort |
gstt1 and gstm1 null variants in mestizo and amerindian populations from northwestern mexico and a literature review |
publisher |
Sociedade Brasileira de Genética |
series |
Genetics and Molecular Biology |
issn |
1678-4685 |
publishDate |
2017-11-01 |
description |
Abstract The GSTT1 and GSTM1 genes are key molecules in cellular detoxification. Null variants in these genes are associated with increase susceptibility to developing different types of cancers. The aim of this study was to determine the prevalence of GSTT1 and GSTM1 null genotypes in Mestizo and Amerindian individuals from the Northwestern region of Mexico, and to compare them with those reported worldwide. GSTT1 and GSTM1 null variants were genotyped by multiplex PCR in 211 Mestizos and 211 Amerindian individuals. Studies reporting on frequency of GSTT1 and GSTM1 null variants worldwide were identified by a PubMed search and their geographic distribution were analyzed. We found no significant differences in the frequency of the null genotype for GSTT1 and GSM1 genes between Mestizo and Amerindian individuals. Worldwide frequencies of the GSTT1 and GSTM1 null genotypes ranges from 0.10 to 0.51, and from 0.11 to 0.67, respectively. Interestingly, in most countries the frequency of the GSTT1 null genotype is common or frequent (76%), whereas the frequency of the GSMT1 null genotype is very frequent or extremely frequent (86%). Thus, ethnic-dependent differences in the prevalence of GSTT1 and GSTM1 null variants may influence the effect of environmental carcinogens in cancer risk. |
topic |
Oxidative stress GSTT1 GSTM1 null variants |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017005027102&lng=en&tlng=en |
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