Sulfur transfer and activation by ubiquitin-like modifier system Uba4•Urm1 link protein urmylation and tRNA thiolation in yeast

Sulfur transfer and activation by ubiquitin-like modifier system Uba4•Urm1 link protein urmylation and tRNA thiolation in yeast

Urm1 is a unique dual-function member of the ubiquitin protein family and conserved from yeast to man. It acts both as a protein modifier in ubiquitin-like urmylation and as a sulfur donor for tRNA thiolation, which in concert with the Elongator pathway forms 5-methoxy-carbonyl-methyl-2-thio (mcm5s2...

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Bibliographic Details
Main Authors: André Jüdes, Alexander Bruch, Roland Klassen, Mark Helm, Raffael Schaffrath
Format: Article
Language:English
Published: Shared Science Publishers OG 2016-10-01
Series:Microbial Cell
Subjects:
Saccharomyces cerevisiae
ubiquitin-like modifier Urm1
protein urmylation
tRNA thiolation
E1-like enzyme Uba4
sulfur transferase Tum1
tRNase zymocin
Online Access:http://microbialcell.com/researcharticles/sulfur-transfer-and-activation-by-ubiquitin-like-modifier-system-uba4%e2%80%a2urm1-link-protein-urmylation-and-trna-thiolation-in-yeast/

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http://microbialcell.com/researcharticles/sulfur-transfer-and-activation-by-ubiquitin-like-modifier-system-uba4%e2%80%a2urm1-link-protein-urmylation-and-trna-thiolation-in-yeast/

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