Optimization of secretion and surface localization of heterologous OVA protein in mycobacteria by using LipY as a carrier

Optimization of secretion and surface localization of heterologous OVA protein in mycobacteria by using LipY as a carrier

Abstract Background Mycobacterium bovis Bacille Calmette-Guérin (BCG) is not only used as a vaccine against tuberculosis but also protects against leprosy and is used as part of bladder cancer treatment to induce a protective immune response. However, protection by BCG vaccination is not optimal. To...

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Bibliographic Details
Main Authors: Maroeska J. Burggraaf, Louis S. Ates, Alexander Speer, Kim van der Kuij, Coen Kuijl, Wilbert Bitter
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Microbial Cell Factories
Subjects:
Heterologous secretion
Mycobacterium
Vaccine
BCG
LipY
ESX
Online Access:http://link.springer.com/article/10.1186/s12934-019-1093-1

Internet

http://link.springer.com/article/10.1186/s12934-019-1093-1

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