NOTCH1 can initiate NF-kappaB activation via cytosolic interactions with components of the T cell signalosome

NOTCH1 can initiate NF-kappaB activation via cytosolic interactions with components of the T cell signalosome

T cell stimulation requires the input and integration of external signals. Signaling through the T cell receptor (TCR) is known to induce formation of the membrane-tethered CBM complex, comprising CARMA1, BCL10 and MALT1, which is required for TCR-mediated NF-kappaB activation. TCR signaling has bee...

Full description

Bibliographic Details
Main Authors: Lisa M Minter, Hyun Mu Shin, Mulualem E Tilahun, Ok Hyun Cho, Karthik eChandiran, Christina Arieta Kuksin, Shilpa eKeerthivasan, Abdul H Fauq, Todd E Golde, Lucio eMiele, Margot eThome, Barbara A Osborne
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Immunology
Subjects:
T cell
PKCθ
NF-B
NOTCH1
non-canonical
CARMA1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00249/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00249/full

Similar Items