Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads

Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads

Synthetic glucocorticoids (GC) are the mainstay therapy for treatment of acute and chronic inflammatory disorders. Due to the high adverse effects associated with long-term use, GC pharmacology has focused since the nineties on more selective GC ligand-binding strategies, classified as selective glu...

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Bibliographic Details
Main Authors: Chandra S. Chirumamilla, Ajay Palagani, Balu Kamaraj, Ken Declerck, Marinus W. C. Verbeek, Ryabtsova Oksana, Karolien De Bosscher, Nadia Bougarne, Bart Ruttens, Kris Gevaert, René Houtman, Winnok H. De Vos, Jurgen Joossens, Pieter Van Der Veken, Koen Augustyns, Xaveer Van Ostade, Annemie Bogaerts, Hans De Winter, Wim Vanden Berghe
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
glucocorticoid receptor
SEGRA
NFkB
electrophilic
covalent warhead
cysteine
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01324/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01324/full

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