Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn’s Disease

Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn’s Disease

A recent randomized study of whipworm Trichuris suis ova (TSO) in ileal Crohn’s disease failed to demonstrate a clinical benefit compared to placebo after 12 weeks. Nonetheless, it has recently been shown that the spontaneous small intestinal inflammatory changes in Nod2-/- (Nucleotide-binding oligo...

Full description

Bibliographic Details
Main Authors: Simon U. Jaeger, Elke Schaeffeler, Stefan Winter, Roman Tremmel, Jürgen Schölmerich, Nisar Malek, Eduard F. Stange, Matthias Schwab, Jan Wehkamp
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
Trichuris suis ova
Crohn’s disease
NOD2
helminths
innate immunity
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00764/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00764/full

Similar Items