Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals.

Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals.

Common genetic variants have been shown to explain a fraction of the inherited variation for many common diseases and quantitative traits, including height, a classic polygenic trait. The extent to which common variation determines the phenotype of highly heritable traits such as height is uncertain...

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Bibliographic Details
Main Authors: Yingleong Chan, Oddgeir L Holmen, Andrew Dauber, Lars Vatten, Aki S Havulinna, Frank Skorpen, Kirsti Kvaløy, Kaisa Silander, Thutrang T Nguyen, Cristen Willer, Michael Boehnke, Markus Perola, Aarno Palotie, Veikko Salomaa, Kristian Hveem, Timothy M Frayling, Joel N Hirschhorn, Michael N Weedon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3248463?pdf=render

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http://europepmc.org/articles/PMC3248463?pdf=render

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