The NLRP3 Inflammasome Promotes Age-Related Thymic Demise and Immunosenescence

The NLRP3 Inflammasome Promotes Age-Related Thymic Demise and Immunosenescence

The collapse of thymic stromal cell microenvironment with age and resultant inability of the thymus to produce naive T cells contributes to lower immune-surveillance in the elderly. Here we show that age-related increase in ‘lipotoxic danger signals’ such as free cholesterol (FC) and ceramides, lea...

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Bibliographic Details
Main Authors: Yun-Hee Youm, Thirumala-Devi Kanneganti, Bolormaa Vandanmagsar, Xuewei Zhu, Anthony Ravussin, Ayinuer Adijiang, John S. Owen, Michael J. Thomas, Joseph Francis, John S. Parks, Vishwa Deep Dixit
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124711000106

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http://www.sciencedirect.com/science/article/pii/S2211124711000106

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