The NLRP3 Inflammasome Promotes Age-Related Thymic Demise and Immunosenescence
The collapse of thymic stromal cell microenvironment with age and resultant inability of the thymus to produce naive T cells contributes to lower immune-surveillance in the elderly. Here we show that age-related increase in ‘lipotoxic danger signals’ such as free cholesterol (FC) and ceramides, lea...
Main Authors: | Yun-Hee Youm, Thirumala-Devi Kanneganti, Bolormaa Vandanmagsar, Xuewei Zhu, Anthony Ravussin, Ayinuer Adijiang, John S. Owen, Michael J. Thomas, Joseph Francis, John S. Parks, Vishwa Deep Dixit |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2012-01-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124711000106 |
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