Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

Macrophages are innate immune cells that adopt diverse activation states in response to their microenvironment. Editing macrophage activation to dampen inflammatory diseases by promoting the repolarization of inflammatory (M1) macrophages to anti-inflammatory (M2) macrophages is of high interest. He...

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Bibliographic Details
Main Authors: Jan Van den Bossche, Jeroen Baardman, Natasja A. Otto, Saskia van der Velden, Annette E. Neele, Susan M. van den Berg, Rosario Luque-Martin, Hung-Jen Chen, Marieke C.S. Boshuizen, Mohamed Ahmed, Marten A. Hoeksema, Alex F. de Vos, Menno P.J. de Winther
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
immunometabolism
macrophage polarization
macrophage plasticity
metabolism
inflammation
mitochondrial dysfunction
M1 M2 polarization
alternative macrophage activation
macrophage repolarization
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471631213X

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http://www.sciencedirect.com/science/article/pii/S221112471631213X

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