Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicity

Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicity

Hsien-Ya Lin, Chia-Yu Chen, Ting-Chien Lin and colleagues perform structure-guided modifications of the compound uronic isofagomaine in order to engineer a highly specific and potent inhibitor of gut bacterial β-glucuronidases (GUSs). The authors present eight crystal structures and demonstrate in v...

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Bibliographic Details
Main Authors: Hsien-Ya Lin, Chia-Yu Chen, Ting-Chien Lin, Lun-Fu Yeh, Wei-Che Hsieh, Shijay Gao, Pierre-Alain Burnouf, Bing-Mae Chen, Tung-Ju Hsieh, Punsaldulam Dashnyam, Yen-Hsi Kuo, Zhijay Tu, Steve R. Roffler, Chun-Hung Lin
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01815-w

Internet

https://doi.org/10.1038/s42003-021-01815-w

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