Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice.

BACKGROUND: Multiple lines of evidence suggest innate immune response pathways to be involved in the development of obesity-associated diabetes although the molecular mechanism underling the disease is unknown. Recent observations suggest that saturated fatty acids can act as a ligand for toll-like...

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Bibliographic Details
Main Authors: Toru Hosoi, Shota Yokoyama, Suguru Matsuo, Shizuo Akira, Koichiro Ozawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2932727?pdf=render