Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel γ-secretase substrates

<p>Abstract</p> <p>Background</p> <p>The mammalian Vps10p sorting receptor family is a group of 5 type I membrane homologs (Sortilin, SorLA, and SorCS1-3). These receptors bind various cargo proteins via their luminal Vps10p domains and have been shown to mediate a vari...

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Bibliographic Details
Main Authors: Nyborg Andrew C, Ladd Thomas B, Zwizinski Craig W, Lah James J, Golde Todd E
Format: Article
Language:English
Published: BMC 2006-06-01
Series:Molecular Neurodegeneration
Online Access:http://www.molecularneurodegeneration.com/content/1/1/3