Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration

Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration

Abstract Several molecular pathways are currently being targeted in attempts to develop disease-modifying therapies to slow down neurodegeneration in Parkinson’s disease. Failure of cellular energy metabolism has long been implicated in sporadic Parkinson’s disease and recent research on rare inheri...

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Bibliographic Details
Main Authors: Emmanuel Quansah, Wouter Peelaerts, J. William Langston, David K. Simon, Jerry Colca, Patrik Brundin
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Molecular Neurodegeneration
Subjects:
Mitochondrial pyruvate carrier
Insulin sensitizers
Neurodegeneration
Parkinson’s disease
Online Access:http://link.springer.com/article/10.1186/s13024-018-0260-x

Internet

http://link.springer.com/article/10.1186/s13024-018-0260-x

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