Inhibition of JAK1/2 Tyrosine Kinases Reduces Neurogenic Heterotopic Ossification After Spinal Cord Injury

Inhibition of JAK1/2 Tyrosine Kinases Reduces Neurogenic Heterotopic Ossification After Spinal Cord Injury

Neurogenic heterotopic ossifications (NHO) are very incapacitating complications of traumatic brain and spinal cord injuries (SCI) which manifest as abnormal formation of bone tissue in periarticular muscles. NHO are debilitating as they cause pain, partial or total joint ankylosis and vascular and...

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Bibliographic Details
Main Authors: Kylie A. Alexander, Hsu-Wen Tseng, Whitney Fleming, Beulah Jose, Marjorie Salga, Irina Kulina, Susan M. Millard, Allison R. Pettit, François Genêt, Jean-Pierre Levesque
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
spinal cord injury complications
heterotopic ossification
JAK- STAT signaling pathway
ruxolitinib
oncostatin M receptor
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00377/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00377/full

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