Genomic Characterization of TP53–Wild-Type Esophageal Carcinoma

Up to 40% of esophageal carcinomas have a biallelic intact TP53 gene. It is largely unclear how these carcinoma cells prevent apoptosis, what is the kind of pathway alterations, or whether therapeutically relevant alterations exist in this subgroup. We evaluated The Cancer Genome Atlas (TCGA) data t...

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Bibliographic Details
Main Authors: Alexander Quaas, Carina Heydt, Florian Gebauer, Hakan Alakus, Heike Loeser, Reinhard Buettner, Axel Hillmer, Christiane Bruns, Sabine Merkelbach-Bruse, Thomas Zander, Peter Frommolt
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523318303899