The Impact of the ‘Mis-Peptidome’ on HLA Class I-Mediated Diseases: Contribution of ERAP1 and ERAP2 and Effects on the Immune Response

The Impact of the ‘Mis-Peptidome’ on HLA Class I-Mediated Diseases: Contribution of ERAP1 and ERAP2 and Effects on the Immune Response

The strong association with the Major Histocompatibility Complex (MHC) class I genes represents a shared trait for a group of autoimmune/autoinflammatory disorders having in common immunopathogenetic basis as well as clinical features. Accordingly, the main risk factors for Ankylosing Spondylitis (A...

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Bibliographic Details
Main Authors: Valentina Tedeschi, Giorgia Paldino, Fabiana Paladini, Benedetta Mattorre, Loretta Tuosto, Rosa Sorrentino, Maria Teresa Fiorillo
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
HLA class I molecules
ERAP1 and ERAP2 ER aminopeptidases
immunopeptidome
autoimmune/autoinflammatory disorders
antigen presentation
CD8<sup>+</sup> T cells
Online Access:https://www.mdpi.com/1422-0067/21/24/9608

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https://www.mdpi.com/1422-0067/21/24/9608

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