Embelin as Lead Compound for New Neuroserpin Polymerization Inhibitors

Embelin as Lead Compound for New Neuroserpin Polymerization Inhibitors

Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is a severe and lethal neurodegenerative disease. Upon specific point mutations in the <i>SERPINI1</i>gene-coding for the human protein neuroserpin (NS) the resulting pathologic NS variants polymerize and accumulate within...

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Bibliographic Details
Main Authors: Cristina Visentin, Loana Musso, Luca Broggini, Francesca Bonato, Rosaria Russo, Claudia Moriconi, Martino Bolognesi, Elena Miranda, Sabrina Dallavalle, Daniele Passarella, Stefano Ricagno
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Life
Subjects:
protein polymerization
drug design
neurodegeneration
Online Access:https://www.mdpi.com/2075-1729/10/7/111

Internet

https://www.mdpi.com/2075-1729/10/7/111

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