Radiolabeled Human Monoclonal Antibody 067-213 has the Potential for Noninvasive Quantification of CD73 Expression

Radiolabeled Human Monoclonal Antibody 067-213 has the Potential for Noninvasive Quantification of CD73 Expression

Background: CD73 is an ectonucleotidase regulating extracellular adenosine concentration and plays an important role in adenosine-mediated immunosuppressive pathways. The efficacy of CD73-targeted therapy depends on the expression levels of CD73; therefore, monitoring CD73 status in cancer patients...

Full description

Bibliographic Details
Main Authors: Hitomi Sudo, Atsushi B. Tsuji, Aya Sugyo, Gene Kurosawa, Yoshikazu Kurosawa, David Alexander, Hiroyuki Tsuda, Tsuneo Saga, Tatsuya Higashi
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
cd73
immune checkpoint
ectonucleotidase
extracellular adenosine
tumor microenvironment
nuclear medicine imaging
stratification of patients
Online Access:https://www.mdpi.com/1422-0067/21/7/2304

Internet

https://www.mdpi.com/1422-0067/21/7/2304

Similar Items