Analysis of TET2 mutations in paroxysmal nocturnal hemoglobinuria (PNH)

Abstract Background Large clonal populations of cells bearing PIG-A mutations are the sine qua non of PNH, but the PIG-A mutation itself is insufficient for clonal expansion. The association between PNH and aplastic anemia supports the immune escape model, but not all PNH patients demonstrate a hist...

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Bibliographic Details
Main Authors: Camille Lobry, Ashish Bains, Leah B. Zamechek, Sherif Ibrahim, Iannis Aifantis, David J. Araten
Format: Article
Published: BMC 2019-08-01
Series:Experimental Hematology & Oncology
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