Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk
B-cell acute lymphoblastic leukaemia (B-ALL) is a common childhood cancer. Here, the authors conducted a meta-analysis with four genome-wide association studies, totalling 5,321 cases and 16,666 controls of European descent, identifying B-ALL risk loci, whose integration with epigenomic profiling in...
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| Format: | Article |
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Nature Publishing Group
2019-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13069-6 |
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doaj-fe499f58e3cb45709aa02c81074cf6192021-05-11T12:06:34ZengNature Publishing GroupNature Communications2041-17232019-11-011011910.1038/s41467-019-13069-6Identification of four novel associations for B-cell acute lymphoblastic leukaemia riskJayaram Vijayakrishnan0Maoxiang Qian1James B. Studd2Wenjian Yang3Ben Kinnersley4Philip J. Law5Peter Broderick6Elizabeth A. Raetz7James Allan8Ching-Hon Pui9Ajay Vora10William E. Evans11Anthony Moorman12Allen Yeoh13Wentao Yang14Chunliang Li15Claus R. Bartram16Charles G. Mullighan17Martin Zimmerman18Stephen P. Hunger19Martin Schrappe20Mary V. Relling21Martin Stanulla22Mignon L. Loh23Richard S. Houlston24Jun J. Yang25Division of Genetics and Epidemiology, The Institute of Cancer ResearchDepartment of Pharmaceutical Sciences, St. Jude Children’s Research HospitalDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDepartment of Pharmaceutical Sciences, St. Jude Children’s Research HospitalDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDivision of Pediatric Hematology and Oncology, New York University Langone HealthNorthern Institute for Cancer Research, Newcastle UniversityDepartment of Oncology, St. Jude Children’s Research HospitalGreat Ormond HospitalDepartment of Pharmaceutical Sciences, St. Jude Children’s Research HospitalWolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle UniversityCentre for Translational Research in Acute Leukaemia, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Pharmaceutical Sciences, St. Jude Children’s Research HospitalDepartment of Tumor Cell Biology, St. Jude Children’s Research HospitalInstitute of Human Genetics, University HospitalDepartment of Oncology, St. Jude Children’s Research HospitalDepartment of Paediatric Haematology and Oncology, Hannover Medical SchoolDepartment of Paediatrics and Centre for Childhood Cancer Research, Children’s Hospital of Philadelphia and the Perelman School of Medicine at The University of PennsylvaniaDepartment of Paediatrics, University Medical Centre Schleswig-HolsteinDepartment of Pharmaceutical Sciences, St. Jude Children’s Research HospitalDepartment of Paediatric Haematology and Oncology, Hannover Medical SchoolDepartment of Pediatrics, Benioff Children’s Hospital and the Helen Diller Family Comprehensive Cancer Center, University of California San FranciscoDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDepartment of Pharmaceutical Sciences, St. Jude Children’s Research HospitalB-cell acute lymphoblastic leukaemia (B-ALL) is a common childhood cancer. Here, the authors conducted a meta-analysis with four genome-wide association studies, totalling 5,321 cases and 16,666 controls of European descent, identifying B-ALL risk loci, whose integration with epigenomic profiling indicates cell-cycle and B-cell development deregulation as central mechanisms in B-ALL susceptibility, often in a subtype-specific fashion.https://doi.org/10.1038/s41467-019-13069-6 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jayaram Vijayakrishnan Maoxiang Qian James B. Studd Wenjian Yang Ben Kinnersley Philip J. Law Peter Broderick Elizabeth A. Raetz James Allan Ching-Hon Pui Ajay Vora William E. Evans Anthony Moorman Allen Yeoh Wentao Yang Chunliang Li Claus R. Bartram Charles G. Mullighan Martin Zimmerman Stephen P. Hunger Martin Schrappe Mary V. Relling Martin Stanulla Mignon L. Loh Richard S. Houlston Jun J. Yang |
| spellingShingle |
Jayaram Vijayakrishnan Maoxiang Qian James B. Studd Wenjian Yang Ben Kinnersley Philip J. Law Peter Broderick Elizabeth A. Raetz James Allan Ching-Hon Pui Ajay Vora William E. Evans Anthony Moorman Allen Yeoh Wentao Yang Chunliang Li Claus R. Bartram Charles G. Mullighan Martin Zimmerman Stephen P. Hunger Martin Schrappe Mary V. Relling Martin Stanulla Mignon L. Loh Richard S. Houlston Jun J. Yang Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk Nature Communications |
| author_facet |
Jayaram Vijayakrishnan Maoxiang Qian James B. Studd Wenjian Yang Ben Kinnersley Philip J. Law Peter Broderick Elizabeth A. Raetz James Allan Ching-Hon Pui Ajay Vora William E. Evans Anthony Moorman Allen Yeoh Wentao Yang Chunliang Li Claus R. Bartram Charles G. Mullighan Martin Zimmerman Stephen P. Hunger Martin Schrappe Mary V. Relling Martin Stanulla Mignon L. Loh Richard S. Houlston Jun J. Yang |
| author_sort |
Jayaram Vijayakrishnan |
| title |
Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk |
| title_short |
Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk |
| title_full |
Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk |
| title_fullStr |
Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk |
| title_full_unstemmed |
Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk |
| title_sort |
identification of four novel associations for b-cell acute lymphoblastic leukaemia risk |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-11-01 |
| description |
B-cell acute lymphoblastic leukaemia (B-ALL) is a common childhood cancer. Here, the authors conducted a meta-analysis with four genome-wide association studies, totalling 5,321 cases and 16,666 controls of European descent, identifying B-ALL risk loci, whose integration with epigenomic profiling indicates cell-cycle and B-cell development deregulation as central mechanisms in B-ALL susceptibility, often in a subtype-specific fashion. |
| url |
https://doi.org/10.1038/s41467-019-13069-6 |
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