Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells.

by John C Panetta, Alex Sparreboom, Ching-Hon Pui, Mary V Relling, William E Evans
Published 2010-12-01

Population PK/PD model of homocysteine concentrations after high-dose methotrexate treatment in patients with acute lymphoblastic leukemia.

by Hauke Rühs, Achim Becker, Anne Drescher, John C Panetta, Ching-Hon Pui, Mary V Relling, Ulrich Jaehde
Published 2012-01-01

A comprehensive evaluation of collapsing methods using simulated and real data: Excellent annotation of functionality and largesample sizes required

by Carmen eDering, Inke R König, Laura B Ramsey, Mary V Relling, Wenjian eYang, Andreas eZiegler, Andreas eZiegler
Published 2014-09-01

Asparaginase Potentiates Glucocorticoid-Induced Osteonecrosis in a Mouse Model.

by Chengcheng Liu, Laura J Janke, Jitesh D Kawedia, Laura B Ramsey, Xiangjun Cai, Leonard A Mattano, Kelli L Boyd, Amy J Funk, Mary V Relling
Published 2016-01-01

Asparaginase combined with discontinuous dexamethasone improves antileukemic efficacy without increasing osteonecrosis in preclinical models.

by Seth E Karol, Laura J Janke, John C Panetta, Laura B Ramsey, Xiangjun Cai, Monique A Payton, David A Jenkins, William E Evans, Mary V Relling
Published 2019-01-01

Concordant gene expression in leukemia cells and normal leukocytes is associated with germline cis-SNPs.

by Deborah French, Wenjian Yang, Leo H Hamilton, Geoffrey Neale, Yiping Fan, James R Downing, Nancy J Cox, Ching-Hon Pui, William E Evans, Mary V Relling
Published 2008-05-01

In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile.

by Michael J Sorich, Nicolas Pottier, Deqing Pei, Wenjian Yang, Leo Kager, Gabriele Stocco, Cheng Cheng, John C Panetta, Ching-Hon Pui, Mary V Relling, Meyling H Cheok, William E Evans
Published 2008-04-01

Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Gr...

by Kelly E. Caudle, Katrin Sangkuhl, Michelle Whirl‐Carrillo, Jesse J. Swen, Cyrine E. Haidar, Teri E. Klein, Roseann S. Gammal, Mary V. Relling, Stuart A. Scott, Daniel L. Hertz, Henk‐Jan Guchelaar, Andrea Gaedigk
Published 2020-01-01

Antileukemic Efficacy of Continuous vs Discontinuous Dexamethasone in Murine Models of Acute Lymphoblastic Leukemia.

by Laura B Ramsey, Laura J Janke, Monique A Payton, Xiangjun Cai, Steven W Paugh, Seth E Karol, Landry Kamdem Kamdem, Cheng Cheng, Richard T Williams, Sima Jeha, Ching-Hon Pui, William E Evans, Mary V Relling
Published 2015-01-01

Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk

by Jayaram Vijayakrishnan, Maoxiang Qian, James B. Studd, Wenjian Yang, Ben Kinnersley, Philip J. Law, Peter Broderick, Elizabeth A. Raetz, James Allan, Ching-Hon Pui, Ajay Vora, William E. Evans, Anthony Moorman, Allen Yeoh, Wentao Yang, Chunliang Li, Claus R. Bartram, Charles G. Mullighan, Martin Zimmerman, Stephen P. Hunger, Martin Schrappe, Mary V. Relling, Martin Stanulla, Mignon L. Loh, Richard S. Houlston, Jun J. Yang
Published 2019-11-01

Identification of small molecules that mitigate vincristine‐induced neurotoxicity while sensitizing leukemia cells to vincristine

by Barthelemy Diouf, Claudia Wing, John C. Panetta, Donnie Eddins, Wenwei Lin, Wenjian Yang, Yiping Fan, Deqing Pei, Cheng Cheng, Shannon M. Delaney, Wei Zhang, Erik J. Bonten, Kristine R. Crews, Steven W. Paugh, Lie Li, Burgess B. Freeman 3rd, Robert J. Autry, Jordan A. Beard, Daniel C. Ferguson, Laura J. Janke, Kirsten K. Ness, Taosheng Chen, Stanislav S. Zakharenko, Sima Jeha, Ching‐Hon Pui, Mary V. Relling, M. Eileen Dolan, William E. Evans
Published 2021-07-01