Ten Years’ Experience with the CYP2D6 Activity Score: A Perspective on Future Investigations to Improve Clinical Predictions for Precision Therapeutics

by Andrea Gaedigk, Jean C. Dinh, Hyunyoung Jeong, Bhagwat Prasad, J. Steven Leeder
Published 2018-04-01

Relationship between CYP2D6 genotype, activity score and phenotype in a pediatric Thai population treated with risperidone

by Yaowaluck Hongkaew, Andrea Gaedigk, Bob Wilffert, Nattawat Ngamsamut, Wiranpat Kittitharaphan, Penkhae Limsila, Chonlaphat Sukasem
Published 2021-02-01

Long-Distance Phasing of a Tentative “Enhancer” Single-Nucleotide Polymorphism With CYP2D6 Star Allele Definitions

by Erin C. Boone, Wendy Y. Wang, Roger Gaedigk, Roger Gaedigk, Mariana Cherner, Anick Bérard, Anick Bérard, J. Steven Leeder, J. Steven Leeder, Neil A. Miller, Neil A. Miller, Andrea Gaedigk, Andrea Gaedigk
Published 2020-05-01

Retrospective Review of Pharmacogenetic Testing at an Academic Children’s Hospital

by Timothy A. Roberts, Jennifer A. Wagner, Tracy Sandritter, Benjamin T. Black, Andrea Gaedigk, Stephani L. Stancil
Published 2021-01-01

Association between CYP2D6 Genotypes and the Risk of Antidepressant Discontinuation, Dosage Modification and the Occurrence of Maternal Depression during Pregnancy

by Anick Bérard, Anick Bérard, Andrea Gaedigk, Andrea Gaedigk, Odile Sheehy, Christina Chambers, Mark Roth, Pina Bozzo, Diana Johnson, Kelly Kao, Sharon Lavigne, Lori Wolfe, Dee Quinn, Kristen Dieter, Jin-Ping Zhao, the OTIS (MotherToBaby) Collaborative Research Committee
Published 2017-07-01

Pharmacogenomics Factors Influencing the Effect of Risperidone on Prolactin Levels in Thai Pediatric Patients With Autism Spectrum Disorder

by Yaowaluck Hongkaew, Yaowaluck Hongkaew, Yaowaluck Hongkaew, Andrea Gaedigk, Andrea Gaedigk, Bob Wilffert, Bob Wilffert, Roger Gaedigk, Roger Gaedigk, Wiranpat Kittitharaphan, Nattawat Ngamsamut, Penkhae Limsila, Apichaya Puangpetch, Apichaya Puangpetch, Rattanaporn Sukprasong, Rattanaporn Sukprasong, Chonlaphat Sukasem, Chonlaphat Sukasem, Chonlaphat Sukasem
Published 2021-10-01

Identification of novel CYP2D7-2D6 hybrids: non-functional and functional variants

by Andrea Gaedigk, Lazara K M Jaime, Joseph S Bertino, Jr, Anick Bérard, Victoria Pratt, L D Bradford, J S Leeder
Published 2010-10-01

Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia

by Jonathan B. Wagner, Susan Abdel‐Rahman, Andrea Gaedigk, Roger Gaedigk, Geetha Raghuveer, Vincent S. Staggs, Leon Van Haandel, J. Steven Leeder
Published 2020-05-01

Transfer learning enables prediction of CYP2D6 haplotype function.

by Gregory McInnes, Rachel Dalton, Katrin Sangkuhl, Michelle Whirl-Carrillo, Seung-Been Lee, Philip S Tsao, Andrea Gaedigk, Russ B Altman, Erica L Woodahl
Published 2020-11-01

PASSPORT-seq: A Novel High-Throughput Bioassay to Functionally Test Polymorphisms in Micro-RNA Target Sites

by Joseph Ipe, Kimberly S. Collins, Kimberly S. Collins, Yangyang Hao, Yangyang Hao, Hongyu Gao, Hongyu Gao, Puja Bhatia, Andrea Gaedigk, Yunlong Liu, Yunlong Liu, Todd C. Skaar
Published 2018-06-01

CYP2D6 Genetic Variation and Its Implication for Vivax Malaria Treatment in Madagascar

by Rajeev K. Mehlotra, Andrea Gaedigk, Rosalind E. Howes, Rosalind E. Howes, Tovonahary A. Rakotomanga, Tovonahary A. Rakotomanga, Arsene C. Ratsimbasoa, Arsene C. Ratsimbasoa, Peter A. Zimmerman
Published 2021-04-01

Warfarin Anticoagulation Therapy in Caribbean Hispanics of Puerto Rico: A Candidate Gene Association Study

by Karla Claudio-Campos, Aurora Labastida, Alga Ramos, Andrea Gaedigk, Jessicca Renta-Torres, Dariana Padilla, Giselle Rivera-Miranda, Stuart A. Scott, Stuart A. Scott, Gualberto Ruaño, Carmen L. Cadilla, Jorge Duconge-Soler
Published 2017-06-01

Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Gr...

by Kelly E. Caudle, Katrin Sangkuhl, Michelle Whirl‐Carrillo, Jesse J. Swen, Cyrine E. Haidar, Teri E. Klein, Roseann S. Gammal, Mary V. Relling, Stuart A. Scott, Daniel L. Hertz, Henk‐Jan Guchelaar, Andrea Gaedigk
Published 2020-01-01

Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6‐Mediated Metabolic Activity

by Rachel Dalton, Seung‐been Lee, Katrina G. Claw, Bhagwat Prasad, Brian R. Phillips, Danny D. Shen, Lai Hong Wong, Mitch Fade, Matthew G. McDonald, Maitreya J. Dunham, Douglas M. Fowler, Allan E. Rettie, Erin Schuetz, Timothy A. Thornton, Deborah A. Nickerson, Andrea Gaedigk, Kenneth E. Thummel, Erica L. Woodahl
Published 2020-01-01