Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy

Abstract Aging is characterized by the progressive loss of physiological function in all organisms. Remarkably, the aging process can be modulated by environmental modifications, including diet and small molecules. The natural compound nordihydroguaiaretic acid (NDGA) robustly increases lifespan in...

Full description

Bibliographic Details
Main Authors: Tugsan Tezil, Manish Chamoli, Che-Ping Ng, Roman P. Simon, Victoria J. Butler, Manfred Jung, Julie Andersen, Aimee W. Kao, Eric Verdin
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:npj Aging and Mechanisms of Disease
Online Access:https://doi.org/10.1038/s41514-019-0037-7

Internet

https://doi.org/10.1038/s41514-019-0037-7

Similar Items