Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells

<p>Abstract</p> <p>Background</p> <p>Signal peptide peptidase (SPP) is an intramembrane cleaving protease identified by its cleavage of several type II membrane signal peptides. Conservation of intramembrane active site residues demonstrates that SPP, SPP family members...

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Bibliographic Details
Main Authors: Nyborg Andrew C, Herl Lauren, Berezovska Oksana, Thomas Anne V, Ladd Thomas B, Jansen Karen, Hyman Bradley T, Golde Todd E
Format: Article
Language:English
Published: BMC 2006-11-01
Series:Molecular Neurodegeneration
Online Access:http://www.molecularneurodegeneration.com/content/1/1/16