Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus.

Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus.

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes global epidemics of a debilitating polyarthritis in humans. As there is a pressing need for the development of therapeutic agents, we screened 230 new mouse anti-CHIKV monoclonal antibodies (MAbs) for their ability to inhibit...

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Bibliographic Details
Main Authors: Pankaj Pal, Kimberly A Dowd, James D Brien, Melissa A Edeling, Sergey Gorlatov, Syd Johnson, Iris Lee, Wataru Akahata, Gary J Nabel, Mareike K S Richter, Jolanda M Smit, Daved H Fremont, Theodore C Pierson, Mark T Heise, Michael S Diamond
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3630103?pdf=render

Internet

http://europepmc.org/articles/PMC3630103?pdf=render

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