ORCA/LRWD1 Regulates Homologous Recombination at ALT-Telomeres by Modulating Heterochromatin Organization

ORCA/LRWD1 Regulates Homologous Recombination at ALT-Telomeres by Modulating Heterochromatin Organization

Summary: Telomeres are maintained by telomerase or in a subset of cancer cells by a homologous recombination (HR)-based mechanism, Alternative Lengthening of Telomeres (ALT). The mechanisms regulating telomere-homeostasis in ALT cells remain unclear. We report that a replication initiator protein, O...

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Bibliographic Details
Main Authors: Rosaline Y.C. Hsu, Yo-Chuen Lin, Christophe Redon, Qinyu Sun, Deepak K. Singh, Yating Wang, Vasudha Aggarwal, Jaba Mitra, Abhijith Matur, Branden Moriarity, Taekjip Ha, Mirit I. Aladjem, Kannanganattu V. Prasanth, Supriya G. Prasanth
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:iScience
Subjects:
Biological Sciences
Molecular Biology
Chromosome Organization
Molecular Structure
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220302224

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http://www.sciencedirect.com/science/article/pii/S2589004220302224

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