Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons

Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons

Rett syndrome (RTT) is caused by mutations of MECP2, a methyl CpG binding protein thought to act as a global transcriptional repressor. Here we show, using an isogenic human embryonic stem cell model of RTT, that MECP2 mutant neurons display key molecular and cellular features of this disorder. Unbi...

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Bibliographic Details
Main Authors: Li, Yun (Author), Wang, Haoyi (Author), Muffat, Julien (Author), Cheng, Albert W (Author), Orlando, David A. (Author), Feldman, Danielle A (Author), Bateup, Helen S (Author), Gao, Qing (Author), Hockemeyer, Dirk (Author), Mitalipova, Maisam (Author), Lewis, Caroline A (Author), Sur, Mriganka (Contributor), Young, Richard A (Author), Jaenisch, Rudolf (Contributor), Loven, Jakob (Author), Vander Heiden, Matthew G. (Contributor), Feldman, Danielle A. (Contributor), Young, Richard A. (Contributor), Lewis, Caroline (Author), Kwok, Show Ming (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Kwok, Show-ming (Contributor), Lewis, Caroline A. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-05-18T17:10:26Z.
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