Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

A major advance in the search for an HIV vaccine has been the development of a near-native Envelope trimer (BG505 SOSIP.664) that can induce robust autologous Tier 2 neutralization. Here, potently neutralizing monoclonal antibodies (nAbs) from rabbits immunized with BG505 SOSIP.664 are shown to reco...

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Bibliographic Details
Main Authors: McCoy, Laura E (Author), van Gils, Marit J (Author), Ozorowski, Gabriel (Author), Messmer, Terrence (Author), Briney, Bryan (Author), Voss, James E (Author), Kulp, Daniel W (Author), Macauley, Matthew S (Author), Sok, Devin (Author), Pauthner, Matthias (Author), Menis, Sergey (Author), Cottrell, Christopher A (Author), Torres, Jonathan L (Author), Hsueh, Jessica (Author), Schief, William R (Author), Wilson, Ian A (Author), Ward, Andrew B (Author), Sanders, Rogier W (Author), Burton, Dennis R (Contributor)
Other Authors: Ragon Institute of MGH, MIT and Harvard (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-10-24T15:46:54Z.
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