Equilibrium and dynamic design principles for binding molecules engineered for reagentless biosensors

Equilibrium and dynamic design principles for binding molecules engineered for reagentless biosensors

Reagentless biosensors rely on the interaction of a binding partner and its target to generate a change in fluorescent signal using an environment-sensitive fluorophore or Förster resonance energy transfer. Binding affinity can exert a significant influence on both the equilibrium and the dynamic r...

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Bibliographic Details
Main Authors: De Picciotto, Seymour (Contributor), Imperiali, Barbara (Contributor), Griffith, Linda G (Contributor), Wittrup, Karl Dane (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-11-17T22:35:45Z.
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