A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy

A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy

In normal cells p53 is activated by DNA damage checkpoint kinases to simultaneously control the G1/S and G2/M cell cycle checkpoints through transcriptional induction of p21[superscript cip1] and Gadd45α. In p53 mutant tumors, cell cycle checkpoints are rewired, leading to dependency on the p38/MK2...

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Bibliographic Details
Main Authors: Grant, Robert A (Author), Tsao, Ming-Sound (Author), Cannell, Ian Gordon (Contributor), Merrick, Karl Andrew (Contributor), Morandell, Sandra M. (Contributor), Grant, Robert A (Contributor), Cameron, Eleanor Ruth (Contributor), Hemann, Michael (Contributor), Yaffe, Michael B (Contributor), Braun, Christian Joerg (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Braun, Christian Jorg (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-12-01T19:41:32Z.
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