The MicroRNA-132 and MicroRNA-212 Cluster Regulates Hematopoietic Stem Cell Maintenance and Survival with Age by Buffering FOXO3 Expression

The MicroRNA-132 and MicroRNA-212 Cluster Regulates Hematopoietic Stem Cell Maintenance and Survival with Age by Buffering FOXO3 Expression

MicroRNAs are critical post-transcriptional regulators of hematopoietic cell-fate decisions, though little remains known about their role in aging hematopoietic stem cells (HSCs). We found that the regulated during aging. Both over-expression and deletion of microRNAs in this cluster leads to inappr...

Full description

Bibliographic Details
Main Authors: Mehta, Arnav (Author), Zhao, Jimmy L (Author), Sinha, Nikita (Author), Marinov, Georgi K (Author), Mann, Mati (Author), Kowalczyk, Monika S (Author), Galimidi, Rachel P (Author), Du, Xiaomi (Author), Erikci, Erdem (Author), Chowdhury, Kamal (Author), Baltimore, David (Author), Regev, Aviv (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Elsevier/Cell Press, 2016-12-07T20:25:09Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items