Antibody-Mediated Neutralization of Perfringolysin O for Intracellular Protein Delivery

Antibody-Mediated Neutralization of Perfringolysin O for Intracellular Protein Delivery

Perfringolysin O (PFO) is a member of the cholesterol-dependent cytolysin (CDC) family of bacterial pore-forming proteins, which are highly efficient in delivering exogenous proteins to the cytoplasm. However, the indiscriminate and potent cytotoxicity of PFO limits its practical use as an intracell...

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Main Authors: Yang, Nicole Jie Yeon (Contributor), Sklaviadis, Demetra (Contributor), Wittrup, Karl Dane (Contributor), Gui, Dan Yi (Contributor), Vander Heiden, Matthew G. (Contributor), Liu, David V. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Liu, David V (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2016-12-15T15:27:23Z.
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