Paired exome analysis of Barrett's esophagus and adenocarcinoma

Paired exome analysis of Barrett's esophagus and adenocarcinoma

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Barrett's esophagus is thought to progress to esophageal adenocarcinoma (EAC) through a stepwise progression with loss of CDKN2A followed by TP53 inactivation and aneuploidy. Here we present whole-exome sequencing from 25 pairs of EAC and Barrett's esophagus and from 5 patients whose Barre...

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Main Authors: Stachler, Matthew D (Author), Taylor-Weiner, Amaro (Author), Peng, Shouyong (Author), McKenna, Aaron (Author), Agoston, Agoston T (Author), Odze, Robert D (Author), Davison, Jon M (Author), Nason, Katie S (Author), Loda, Massimo (Author), Leshchiner, Ignaty (Author), Stewart, Chip (Author), Stojanov, Petar (Author), Seepo, Sara (Author), Lawrence, Michael S (Author), Ferrer-Torres, Daysha (Author), Lin, Jules (Author), Chang, Andrew C (Author), Gabriel, Stacey B (Author), Beer, David G (Author), Getz, Gad (Author), Carter, Scott L (Author), Bass, Adam J (Author), Lander, Eric Steven (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-01-23T19:22:26Z.
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