Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

While the catalog of mammalian transcripts and their expression levels in different cell types and disease states is rapidly expanding, our understanding of transcript function lags behind. We present a robust technology enabling systematic investigation of the cellular consequences of repressing or...

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Bibliographic Details
Main Authors: Gilbert, Luke A (Author), Horlbeck, Max A (Author), Adamson, Britt (Author), Villalta, Jacqueline E (Author), Chen, Yuwen (Author), Whitehead, Evan H (Author), Guimaraes, Carla (Author), Panning, Barbara (Author), Bassik, Michael C (Author), Qi, Lei S (Author), Kampmann, Martin (Author), Weissman, Jonathan S (Author), Ploegh, Hidde (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-04-10T15:27:17Z.
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