CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

The MYC oncoproteins are thought to stimulate tumor cell growth and proliferation through amplification of gene transcription, a mechanism that has thwarted most efforts to inhibit MYC function as potential cancer therapy. Using a covalent inhibitor of cyclin-dependent kinase 7 (CDK7) to disrupt the...

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Main Authors: Chipumuro, Edmond (Author), Marco, Eugenio (Author), Christensen, Camilla L (Author), Zhang, Tinghu (Author), Hatheway, Clark M (Author), Sharma, Bandana (Author), Yeung, Caleb (Author), Altabef, Abigail (Author), Perez-Atayde, Antonio (Author), Wong, Kwok-Kin (Author), Yuan, Guo-Cheng (Author), Gray, Nathanael S (Author), George, Rani E (Author), Kwiatkowski, Nick (Contributor), Abraham, Brian Joseph (Contributor), Young, Richard A. (Author)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Young, Richard A (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-04-10T15:57:15Z.
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